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中华肾病研究电子杂志 ›› 2017, Vol. 06 ›› Issue (01) : 39 -43. doi: 10.3877/cma.j.issn.2095-3216.2017.01.009

所属专题: 文献

综述

饮食限制对肾损伤的保护作用
王思扬1, 蔡广研1,()   
  1. 1. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心
  • 收稿日期:2016-12-09 出版日期:2017-02-28
  • 通信作者: 蔡广研
  • 基金资助:
    国家科技支撑计划课题(2015BAI12B06); 国家973计划课题(2013CB530805)

Dietary restriction in renal protection

Siyang Wang1, Guangyan Cai1,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Received:2016-12-09 Published:2017-02-28
  • Corresponding author: Guangyan Cai
  • About author:
    Corresponding author: Cai Guangyan, Email:
引用本文:

王思扬, 蔡广研. 饮食限制对肾损伤的保护作用[J/OL]. 中华肾病研究电子杂志, 2017, 06(01): 39-43.

Siyang Wang, Guangyan Cai. Dietary restriction in renal protection[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(01): 39-43.

饮食限制(DR)又名为热量限制(CR),现已成为一种新的干预方式被广泛研究。其延长寿命作用已被充分证明,如可明显延长如果蝇、蠕虫、啮齿类及哺乳类动物模型的寿命。调整饮食总的热量或者其中某些营养组分的摄入以及模拟限食药物对衰老相关肾脏疾病和急性、慢性肾脏损伤同样具有预防或者干预作用。其机制涉及增加自噬,减轻炎症和氧化应激,增加胰岛素敏感性,上调SIRT1等。通过对CR相关机制的深入研究,进而提出更加精准的饮食或药物干预方案,对于肾脏的保护具有重要意义。

Dietary restriction, also called calorie restriction, is now widely studied as a new intervention. Its effect of prolonging life has been fully demonstrated. For example, it can significantly extend lifespan of the fly, worms, rodents, and mammalian models. Adjusting the intake of total calorie or some nutrients also has prophylactic or therapeutic effects on aging-related kidney disease and acute or chronic kidney injury. Calorie restriction mimetics has also been studied deeply. The mechanisms of the protection involve increased autophagy, reduced inflammation and oxidative stress, increased insulin sensitivity, and up-regulation of SIRT1, etc. It is important to carry out deep researches on the mechanism of calorie restriction so as to recommend more accurate intervention plans of diets or drugs.

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