切换至 "中华医学电子期刊资源库"

中华肾病研究电子杂志 ›› 2019, Vol. 08 ›› Issue (02) : 85 -90. doi: 10.3877/cma.j.issn.2095-3216.2019.02.008

所属专题: 文献

综述

糖尿病肾病与糖尿病视网膜病变的相关性研究进展
成海梅1, 张利2, 陈香美1,()   
  1. 1. 510006 广州,广东药科大学;100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室(2011DAV00088)、国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室
    2. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室(2011DAV00088)、国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室
  • 收稿日期:2018-10-15 出版日期:2019-04-28
  • 通信作者: 陈香美
  • 基金资助:
    国家重点研发计划(2016YFC1305503); 国家自然科学基金青年项目(81700629); 北京市科技计划项目(D171100002817002); 国家"973"计划项目(2015CB553605)

Advances in research on the relationship between diabetic nephropathy and diabetic retinopathy

Haimei Cheng1, Li Zhang2, Xiangmei Chen1,()   

  1. 1. Guangdong Pharmaceutical University, Guangzhou 510006; Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853; China
    2. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853; China
  • Received:2018-10-15 Published:2019-04-28
  • Corresponding author: Xiangmei Chen
  • About author:
    Corresponding author: Chen Xiangmei, Email:
引用本文:

成海梅, 张利, 陈香美. 糖尿病肾病与糖尿病视网膜病变的相关性研究进展[J/OL]. 中华肾病研究电子杂志, 2019, 08(02): 85-90.

Haimei Cheng, Li Zhang, Xiangmei Chen. Advances in research on the relationship between diabetic nephropathy and diabetic retinopathy[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2019, 08(02): 85-90.

糖尿病肾病(DN)和糖尿病视网膜病变(DR)均是糖尿病的微血管病变,是目前成人终末期肾病(ESRD)和致盲的重要原因,两者在发生、发展过程中具有一定平行性,又存在不平行性。DN和DR可预测彼此的发生、发展,但目前对于两者之间的关系尚未明确。因此,本文就DN与DR之间的相关性的研究进展作一综述,为临床诊断治疗提供帮助。

Diabetic nephropathy (DN) and diabetic retinopathy (DR) both belong to the microangiopathy of diabetes, being important causes of end-stage renal disease (ESRD) and blindness in adults. They have both certain parallelism and non-parallelism in their development and progression. DN index or DR index can be used for predicting the development and progression of each other, but the relationship between them has so far not been clearly described. Therefore, this article reviewed the research progress of the correlation between DN and DR, in order to provide assistance for the clinical diagnosis and treatment.

图1 糖尿病肾病和糖尿病视网膜病变的发病机制的异同
图2 糖尿病肾病与糖尿病视网膜病变的临床与病理表现的相似性
[1]
Cho NH, Shaw JE, Karuranga S, et al. IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045 [J]. Diabetes Res Clin Pract, 2018, 138:271-281.
[2]
Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults [J]. JAMA, 2013, 310(9):948-959.
[3]
Zhang X, Saaddine JB, Chou CF, et al. Prevalence of diabetic retinopathy in the United States, 2005-2008 [J]. JAMA, 2010, 304(6):649-656.
[4]
Kandarakis SA, Piperi C, Topouzis F, et al. Emerging role of advanced glycation-end products (AGEs) in the pathobiology of eye diseases [J]. Prog Retin Eye Res, 2014, 42:85-102.
[5]
Maeda S, Matsui T, Ojima A, et al. Sulforaphane inhibits advanced glycation end product-induced pericyte damage by reducing expression of receptor for advanced glycation end products [J]. Nutr Res, 2014, 34(9):807-813.
[6]
Sasai Y, Iwakawa K, Yanagida K, et al. Advanced glycation endproducts stimulate renal epithelial cells to release chemokines that recruit macrophages, leading to renal fibrosis [J]. Biosci Biotechnol Biochem, 2012, 76(9):1741-1745.
[7]
Deng X, Sun L, Lai X, et al. Tea polypeptide ameliorates diabetic nephropathy through RAGE and NF-kappa B signaling pathway in type 2 diabetes mice [J]. J Agric Food Chem, 2018, 66(45):11957-11967.
[8]
Lewko B, Latawiec E, Maryn A, et al. Osmolarity and glucose differentially regulate aldose reductase activity in cultured mouse podocytes [J]. Exp Diabetes Res, 2011, 2011:278963.
[9]
Cheng CL, Tang Y, Zheng Z, et al. Advanced glycation end-products activate the renin-angiotensin system through the RAGE/PI3-K signaling pathway in podocytes [J]. Clin Invest Med, 2012, 35(5):E282.
[10]
Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, et al. Cellular death, reactive oxygen species (ROS) and diabetic complications [J]. Cell Death Dis, 2018, 9(2):119.
[11]
Li J, Wang JJ, Zhang SX. NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy [J]. J Diabetes Res, 2015, 2015:963289.
[12]
Geraldes P, King GL. Activation of protein kinase C isoforms and its impact on diabetic complications [J]. Circ Res, 2010, 106(8):1319-1331.
[13]
Parveen A, Kim JH, Oh BG, et al. Phytochemicals: target-based therapeutic strategies for diabetic retinopathy [J]. Molecules, 2018, 23(7):E1519.
[14]
Liu H, Cai M. Effect of probucol on hemodynamics, rheology and blood lipid of diabetic retinopathy [J]. Exp Ther Med, 2018, 15(4):3809-3814.
[15]
Mauer M, Zinman B, Gardiner R, et al. Renal and retinal effects of enalapril and losartan in type 1 diabetes [J]. N Engl J Med, 2009, 361(1):40-51.
[16]
Sun CY, Lee CC, Hsieh MF, et al. Clinical association of circulating VEGF-B levels with hyperlipidemia and target organ damage in type 2 diabetic patients [J]. J Biol Regul Homeost Agents, 2014, 28(2):225-236.
[17]
Gupta N, Mansoor S, Sharma A, et al. Diabetic retinopathy and VEGF [J]. Open Ophthalmol J, 2013, 7:4-10.
[18]
Veron D, Reidy KJ, Bertuccio C, et al. Overexpression of VEGF-A in podocytes of adult mice causes glomerular disease [J]. Kidney Int, 2010, 77(11):989-999.
[19]
Oltean S, Qiu Y, Ferguson JK, et al. Vascular endothelial growth factor-A165b is protective and restores endothelial glycocalyx in diabetic nephropathy [J]. J Am Soc Nephrol, 2015, 26(8):1889-1904.
[20]
Arar NH, Freedman BI, Adler SG, et al. Heritability of the severity of diabetic retinopathy: the FIND-Eye study [J]. Invest Ophthalmol Vis Sci, 2008, 49(9):3839-3845.
[21]
Looker HC, Nelson RG, Chew E, et al. Genome-wide linkage analyses to identify loci for diabetic retinopathy [J]. Diabetes, 2007, 56(4):1160-1166.
[22]
Stem MS, Gardner TW. Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications [J]. Curr Med Chem, 2013, 20(26):3241-3250.
[23]
Liu H, Ren JG, Cooper WL, et al. Identification of the antivasopermeability effect of pigment epithelium-derived factor and its active site [J]. Proc Natl Acad Sci USA, 2004, 101(17):6605-6610.
[24]
Klein R, Knudtson MD, Klein BE, et al. The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes [J]. Diabetologia, 2010, 53(8):1638-1646.
[25]
El-Asrar AM, Al-Rubeaan KA, Al-Amro SA, et al. Retinopathy as a predictor of other diabetic complications [J]. Int Ophthalmol, 2001, 24(1):1-11.
[26]
He F, Xia X, Wu XF, et al. Diabetic retinopathy in predicting diabetic nephropathy in patients with type 2 diabetes and renal disease: a meta-analysis [J]. Diabetologia, 2013, 56(3):457-466.
[27]
Liang S, Zhang XG, Cai GY, et al. Identifying parameters to distinguish non-diabetic renal diseases from diabetic nephropathy in patients with type 2 diabetes mellitus: a meta-analysis [J]. PLoS One, 2013, 8(5):e64184.
[28]
Chang TI, Park JT, Kim JK, et al. Renal outcomes in patients with type 2 diabetes with or without coexisting non-diabetic renal disease [J]. Diabetes Res Clin Pract, 2011, 92(2):198-204.
[29]
Oh SW, Kim S, Na KY, et al. Clinical implications of pathologic diagnosis and classification for diabetic nephropathy [J]. Diabetes Res Clin Pract, 2012, 97(3):418-424.
[30]
Wong TY, Choi PC, Szeto CC, et al. Renal outcome in type 2 diabetic patients with or without coexisting nondiabetic nephropathies [J]. Diabetes Care, 2002, 25(5):900-905.
[31]
Olsen S, Mogensen CE. How often is NIDDM complicated with non-diabetic renal disease? An analysis of renal biopsies and the literature [J]. Diabetologia, 1996, 39(12):1638-1645.
[32]
Hung CC, Lin HY, Hwang DY, et al. Diabetic retinopathy and clinical parameters favoring the presence of diabetic nephropathy could predict renal outcome in patients with diabetic kidney disease [J]. Sci Rep, 2017, 7(1):1236.
[33]
Zhang J, Wang Y, Li L, et al. Diabetic retinopathy may predict the renal outcomes of patients with diabetic nephropathy [J]. Ren Fail, 2018, 40(1):243-251.
[34]
Jeng CJ, Hsieh YT, Yang CM, et al. Diabetic retinopathy in patients with diabetic nephropathy: development and progression [J]. PLoS One, 2016, 11(8):e0161897.
[35]
Wolf G, Muller N, Mandecka A, et al. Association of diabetic retinopathy and renal function in patients with types 1 and 2 diabetes mellitus [J]. Clin Nephrol, 2007, 68(2):81-86.
[36]
Chen YH, Chen HS, Tarng DC. More impact of microalbuminuria on retinopathy than moderately reduced GFR among type 2 diabetic patients [J]. Diabetes Care, 2012, 35(4):803-808.
[37]
Wang W, Lo ACY. Diabetic retinopathy: pathophysiology and treatments [J]. Int J Mol Sci, 2018, 19(6):E1816.
[38]
Klein R, Klein BE, Moss SE, et al. The Wisconsin epidemiologic study of diabetic retinopathy. Ⅱ. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years [J]. Arch Ophthalmol, 1984, 102(4):520-526.
[39]
Varma R, Torres M, Pena F, et al. Prevalence of diabetic retinopathy in adult Latinos: the Los Angeles Latino eye study [J]. Ophthalmology, 2004, 111(7):1298-1306.
[40]
Parving HH, Mogensen CE, Thomas MC, et al. Poor prognosis in proteinuric type 2 diabetic patients with retinopathy: insights from the RENAAL study [J]. QJM, 2005, 98(2):119-126.
[41]
Hovind P, Tarnow L, Rossing P, et al. Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study [J]. BMJ, 2004, 328(7448):1105.
[42]
Klein R, Zinman B, Gardiner R, et al. The relationship of diabetic retinopathy to preclinical diabetic glomerulopathy lesions in type 1 diabetic patients: the Renin-Angiotensin System Study [J]. Diabetes, 2005, 54(2):527-533.
[43]
Man RE, Sasongko MB, Wang JJ, et al. The association of estimated glomerular filtration rate with diabetic retinopathy and macular edema [J]. Invest Ophthalmol Vis Sci, 2015, 56(8):4810-4816.
[44]
KDOQI. KDOQI clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease [J]. Am J Kidney Dis, 2007, 49(2 Suppl 2):S12-S154.
[45]
Christensen PK, Larsen S, Horn T, et al. Causes of albuminuria in patients with type 2 diabetes without diabetic retinopathy [J]. Kidney Int, 2000, 58(4):1719-1731.
[46]
Horvatic I, Tisljar M, Kacinari P, et al. Non-diabetic renal disease in Croatian patients with type 2 diabetes mellitus [J]. Diabetes Res Clin Pract, 2014, 104(3):443-450.
[47]
Zhou J, Chen X, Xie Y, et al. A differential diagnostic model of diabetic nephropathy and non-diabetic renal diseases [J]. Nephrol Dial Transplant, 2008, 23(6):1940-1945.
[48]
Liu MY, Chen XM, Sun XF, et al. Validation of a differential diagnostic model of diabetic nephropathy and non-diabetic renal diseases and the establishment of a new diagnostic model [J]. J Diabetes, 2014, 6(6):519-526.
[49]
Parving HH, Gall MA, Skott P, et al. Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients [J]. Kidney Int, 1992, 41(4):758-762.
[50]
Dong Z, Wang Y, Qiu Q, et al. Clinical predictors differentiating non-diabetic renal diseases from diabetic nephropathy in a large population of type 2 diabetes patients [J]. Diabetes Res Clin Pract, 2016, 121:112-118.
[51]
Sacks FM, Hermans MP, Fioretto P, et al. Association between plasma triglycerides and high-density lipoprotein cholesterol and microvascular kidney disease and retinopathy in type 2 diabetes mellitus: a global case-control study in 13 countries [J]. Circulation, 2014, 129(9):999-1008.
[52]
Shah K, Gandhi A, Natarajan S. Diabetic retinopathy awareness and associations with multiple comorbidities: insights from DIAMOND study [J]. Indian J Endocrinol Metab, 2018, 22(1):30-35.
[53]
Yun KJ, Kim HJ, Kim MK, et al. Risk factors for the development and progression of diabetic kidney disease in patients with type 2 diabetes mellitus and advanced diabetic retinopathy [J]. Diabetes Metab J, 2016, 40(6):473-481.
[54]
de Carvalho JA, Tatsch E, Hausen BS, et al. Urinary kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin as indicators of tubular damage in normoalbuminuric patients with type 2 diabetes [J]. Clin Biochem, 2016, 49(3):232-236.
[55]
Dubin RF, Judd S, Scherzer R, et al. Urinary tubular injury biomarkers are associated with ESRD and death in the REGARDS study [J]. Kidney Int Rep, 2018, 3(5):1183-1192.
[56]
Tuttle KR, Bakris GL, Bilous RW, et al. Diabetic kidney disease: a report from an ADA consensus conference [J]. Am J Kidney Dis, 2014, 64(4):510-533.
[57]
Klessens CQ, Woutman TD, Veraar KA, et al. An autopsy study suggests that diabetic nephropathy is underdiagnosed [J]. Kidney Int, 2016, 90(1):149-156.
[1] 王培蕾, 夏罕生, 俞清, 闻捷先, 黄备建. IgG4相关性乳腺炎多模态影像学表现及其治疗转归一例[J/OL]. 中华乳腺病杂志(电子版), 2024, 18(04): 244-247.
[2] 诸琴红, 夏典平, 葛芳娣, 崔大伟. 抗氧化和炎症指标在糖尿病肾病患者中的临床意义[J/OL]. 中华危重症医学杂志(电子版), 2024, 17(04): 307-311.
[3] 陈嘉艺, 陈佳, 张曦, 张琦. 伴有“反晕征”的IgG4 相关性肺疾病一例并文献复习[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 844-846.
[4] 杨柳, 陈佳, 孙雅娟, 陈娇, 谭明超, 龚明福. 抗中性粒细胞胞浆抗体相关性血管炎的胸部CT 及临床特征分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 744-749.
[5] 刘春军, 严方方, 王宝锋, 常婷婷, 郭红红, 李志强. 替加环素联合人免疫球蛋白治疗XDRAB致VAP 的疗效分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(05): 797-800.
[6] 李多, 郝昭昭, 陈延伟, 南岩东. 血清PTX3表达与非小细胞肺癌骨转移的相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 558-562.
[7] 燕红玲, 王岩岩, 陈树斌. PCT、NLR联合LUBS预测ICU CRKP致呼吸机相关肺炎撤机及预后分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 617-620.
[8] 张怡, 王宇洋, 司梦娇, 曹燕, 李欢欢. 脑卒中前白蛋白与肺炎发生风险相关性分析[J/OL]. 中华肺部疾病杂志(电子版), 2024, 17(04): 648-651.
[9] 王涛, 刘静, 高玉伟, 王兴华, 胡秀红, 崔红蕊, 徐保振, 杨洪娟. 抗生素耐药背景下中医药防治腹膜透析相关性腹膜炎研究进展[J/OL]. 中华肾病研究电子杂志, 2024, 13(06): 340-344.
[10] 刘思含, 张静. 老年人血清铁与C 反应蛋白的比值及25-羟基维生素D3 与肾功能受损的关系研究[J/OL]. 中华肾病研究电子杂志, 2024, 13(05): 268-272.
[11] 杨森, 阙玉梅, 丁莉, 王艺瑾, 侯庆宇. Hcy和AD7c-NTP在阿尔茨海默病诊断中的临床应用[J/OL]. 中华脑科疾病与康复杂志(电子版), 2024, 14(04): 208-212.
[12] 邱岭, 朱旭丽, 浦坚, 邢苗苗, 吴佳玲. 糖尿病肾病患者肠道菌群生态特点与胃肠道功能障碍的关联性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(05): 453-458.
[13] 唐小久, 胡曼, 许必君, 肖亚. 肥胖合并胃食管反流病患者严重程度与其焦虑抑郁及营养状态的相关性研究[J/OL]. 中华消化病与影像杂志(电子版), 2024, 14(04): 360-364.
[14] 刘志超, 胡风云, 温春丽. 山西省脑卒中危险因素与地域的相关性分析[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 424-433.
[15] 李璇, 邓岚, 郭微, 邓永梅, 刘杰昕. 标准化皮肤管理流程在防治脑卒中患者失禁相关性皮炎中的应用[J/OL]. 中华脑血管病杂志(电子版), 2024, 18(05): 479-482.
阅读次数
全文


摘要