探讨和总结我国中西医结合肾病学科奠基人之一、上海市名中医陈以平教授治疗IgA肾病的临床经验和用药规律。

收集陈教授治疗IgA肾病典型医案500份，通过"中医传承辅助平台"软件，对用药特点、配伍规律、随证加减、治则治法等进行数据挖掘及聚类分析。总结陈以平教授对于IgA肾病不同临床表现的常用治法及方药。通过熵聚类研究分析常见症状的常用药味组合。

共500份病例纳入研究，共计1 499条医案；共得251味药物，常用中药出现频次从高到低分别为白术、苍术、生黄芪、薏苡仁、黄精等20味。以血尿为主，治以滋阴清热、健脾化湿法。以蛋白尿为主，治以疏利少阳、健脾益肾法。以慢性肾功能不全为主，治以斡旋三焦、活血泄浊法。以肾功能不全伴高尿酸血症为主，治以益肾泄浊、活血通络法。

通过数据挖掘技术以方测证，佐证了陈老治疗IgA肾病寒温并用、苦辛并进、攻补兼施，疏利三焦的学术思想。

To explore and summarize the clinical experience and medication rules in IgA nephropathy by the famous Chinese doctor Chen Yiping, one of the founders of the nephrology of integrated traditional Chinese and western medicine in China.

Data of 500 typical cases of IgA nephropathy treated by Professor Chen Yiping were collected. The "TCM Inheritance Support System" (V2.5) was used for data mining and cluster analysis in terms of drug characteristics, compatibility rules, addition and subtraction with the syndrome, and treatment principles and methods. The common methods and prescriptions of Professor Chen Yiping for different clinical manifestations of IgA nephropathy were summarized. Entropy clustering was used to analyze the common medicine pairs for common symptoms.

500 cases were included in the study, with a total of 1, 499 medical records. Totally, 251 kinds of drugs were used. The frequencies of 20 common traditional Chinese medicines used from high to low were Atractylodes rhizome, raw Astragalus, Coix seed, and Polygonati rhizome, etc. For IgA nephropathy characterized by hematuria, the method of nourishing Yin and clearing heat as well as invigorating the spleen and eliminating dampness was used. For IgA nephropathy characterized by proteinuria, the method of smoothing Shaoyang as well as nourishing the spleen and kidneys was used. For IgA nephropathy characterized by chronic renal insufficiency, the method of mediating Sanjiao as well as activating the blood circulation and draining the turbidity was used. For IgA nephropathy characterized by renal insufficiency complicated with hyperuricemia, the method of tonifying the kidneys as well as activating the blood circulation and draining the turbidity was used.

By means of the data mining techniques, the results supports the academic ideas of Professor Chen Yiping in the treatment of IgA nephropathy through combination of both cold and warm medicines, both bitter and hot medicines, both tonification and purgation medicines, and the method of clearing the Sanjiao.