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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (01) : 33 -37. doi: 10.3877/cma.j.issn.2095-3216.2020.01.007

所属专题: 文献

综述

慢性肾脏病合并高血压的新机制
冯晋1, 张爱华2,()   
  1. 1. 100191 北京大学第三医院肾内科
    2. 100053 首都医科大学宣武医院
  • 收稿日期:2019-04-28 出版日期:2020-02-28
  • 通信作者: 张爱华
  • 基金资助:
    国家自然科学基金项目(81170706)

New mechanisms of hypertension in chronic kidney disease

Jin Feng1, Aihua Zhang2,()   

  1. 1. Department of Nephrology, The Third Hospital of Peking University, Beijing 100191, China
    2. Department of Nephrology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
  • Received:2019-04-28 Published:2020-02-28
  • Corresponding author: Aihua Zhang
  • About author:
    Corresponding author: Zhang Aihua, Email:
引用本文:

冯晋, 张爱华. 慢性肾脏病合并高血压的新机制[J/OL]. 中华肾病研究电子杂志, 2020, 09(01): 33-37.

Jin Feng, Aihua Zhang. New mechanisms of hypertension in chronic kidney disease[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(01): 33-37.

高血压既是CKD的病因,又是CKD进展的重要危险因素,也是发生心脑血管事件的重要危险因素。除了经典发病机制,近年来发现,免疫因素、微小RNA、脑脊液的交感神经系统活性增加、皮肤淋巴回流障碍、血管平滑肌细胞PPAR-γ信号被干预,导致自主神经功能不全等新机制,也参与了肾脏病合并高血压的发病,本文对这些新机制进行了综述。

Hypertension is not only involved in the etiology of CKD, but also an important risk factor for both the progression of CKD and the cardiovascular and cerebrovascular events. In addition to the classic pathogenesis of hypertension in CKD, new mechanisms have also been found in recent years, including immune factors, microRNAs, increase of the sympathetic nervous system activity in cerebrospinal fluid, disorder of cutaneous lymphatic reflux, and intervention of PPAR-γ signals in vascular smooth muscle cells leading to autonomic dysfunction. These new mechanisms were reviewed in this article.

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