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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (03) : 124 -126. doi: 10.3877/cma.j.issn.2095-3216.2020.03.007

所属专题: 文献

综述

从细胞角度探讨毛细血管稀疏与肾间质纤维化
魏雪娇1, 张洋洋1, 朱晓宇1, 黄秀1, 姜丽丽1, 赵丹1, 龙梦团1, 杜玉君1,()   
  1. 1. 130021 长春,吉林大学第一医院肾病科
  • 收稿日期:2020-01-04 出版日期:2020-06-28
  • 通信作者: 杜玉君

Capillary rarefaction and renal interstitial fibrosis: a cellular perspective

Xuejiao Wei1, Yangyang Zhang1, Xiaoyu Zhu1, Xiu Huang1, Lili Jiang1, Dan Zhao1, Mengtuan Long1, Yujun Du1,()   

  1. 1. Department of Nephrology, First Hospital of Jilin University, Changchun 130021, Jilin Province, China
  • Received:2020-01-04 Published:2020-06-28
  • Corresponding author: Yujun Du
  • About author:
    Corresponding author: Du Yujun, Email:
引用本文:

魏雪娇, 张洋洋, 朱晓宇, 黄秀, 姜丽丽, 赵丹, 龙梦团, 杜玉君. 从细胞角度探讨毛细血管稀疏与肾间质纤维化[J]. 中华肾病研究电子杂志, 2020, 09(03): 124-126.

Xuejiao Wei, Yangyang Zhang, Xiaoyu Zhu, Xiu Huang, Lili Jiang, Dan Zhao, Mengtuan Long, Yujun Du. Capillary rarefaction and renal interstitial fibrosis: a cellular perspective[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(03): 124-126.

肾脏毛细血管稀疏既是慢性肾脏病(CKD)导致的结果,又是促进CKD向肾间质纤维化(RIF)进展的关键环节。了解可能造成毛细血管稀疏的发生机制,对探讨改善血管稀疏状态,促进血管新生,减少RIF的发生发展具有重要意义。本文拟从肾脏毛细血管周围细胞即内皮细胞、周细胞及内皮祖细胞着手,对其可能影响肾脏正常血管网结构的病理生理过程及其可能参与血管新生的修复机制作一综述,从而为减轻RIF、延缓CKD进展提供新的治疗思路。

Capillary rarefaction of the kidney is not only a result of CKD, but also a crucial link to promote the progression of CKD to renal interstitial fibrosis (RIF). Learning about the mechanism that may cause the renal capillary rarefaction is of great significance for improving vascular rarefaction and angiogenesis, as well as reducing the development of RIF. This review started with the renal cells around capillaries, such as endothelial cells, pericytes, and endothelial progenitor cells, then summarized their pathophysiological processes that may affect the normal vascular network structure of the kidney and their possible involvement in the repair mechanism of angiogenesis, so as to provide new treatment ideas for improving RIF and slowing down the CKD progression.

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