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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (03) : 127 -130. doi: 10.3877/cma.j.issn.2095-3216.2020.03.008

所属专题: 文献

综述

新型冠状病毒病(COVID-19)与肾脏损伤
杨光1, 刘洋1, 赵佳慧1, 程庆砾1,()   
  1. 1. 100853 北京,解放军总医院第二医学中心肾脏病科 国家老年疾病临床医学研究中心
  • 收稿日期:2019-12-05 出版日期:2020-06-28
  • 通信作者: 程庆砾
  • 基金资助:
    国家老年疾病临床医学研究中心开放课题(NCRCC-PLAGH-2018012); 解放军总医院第二医学中心保健课题(NLBJ-2019006)

New coronavirus disease (COVID-19) and kidney injury

Guang Yang1, Yang Liu1, Jiahui Zhao1, Qingli Cheng1,()   

  1. 1. Department of Nephrology, Second Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Geriatric Diseases, Beijing 100853, China
  • Received:2019-12-05 Published:2020-06-28
  • Corresponding author: Qingli Cheng
  • About author:
    Corresponding author: Cheng Qingli, Email:
引用本文:

杨光, 刘洋, 赵佳慧, 程庆砾. 新型冠状病毒病(COVID-19)与肾脏损伤[J/OL]. 中华肾病研究电子杂志, 2020, 09(03): 127-130.

Guang Yang, Yang Liu, Jiahui Zhao, Qingli Cheng. New coronavirus disease (COVID-19) and kidney injury[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(03): 127-130.

新冠状病毒病(COVID-19)自2019年12月在我国发现以来,目前已在全球213个国家爆发,540多万人受累,并导致近35万人死亡,WHO将其定义为全球大流行。COVID-19除了表现为呼吸系统病变,在重症患者还可能合并有其他脏器损伤,部分患者可出现肾脏损伤,如发生血尿、蛋白尿,血尿素氮或血清肌酐水平升高等;危重症患者中急性肾损伤的发生率较高且影响患者预后。本文将从COVID-19患者肾损伤流行病学及临床特点、发病机制、病理表现、治疗和预后等方面综述,希望能从肾脏病专科角度为COVID-19的防控提供相关信息。

Since its discovery in China in December 2019, the new coronavirus disease (COVID-19) has now broken out in 213 countries around the world, affecting more than 5.4 million people and causing the death of nearly 350, 000 people. WHO has defined it as a global pandemic. In addition to respiratory system involvement, COVID-19 was also accompanied by other organs injuries, especially in severely ill patients, some of whom showed kidney damage manifesting as hematuria, proteinuria, and increased levels of blood urea nitrogen or serum creatinine. The incidence of acute kidney injury in critically ill patients was high and it affected their prognosis. This article reviewed the epidemiology, clinical features, pathogenesis, pathological manifestations, treatment, and prognosis of kidney injury in COVID-19 patients, hoping to provide relevant information for the prevention and control of COVID-19 from the perspective of nephrology.

[1]
World Health Organization. Report of the WHO-China joint mission on coronavirus disease 2019 (COVID-19) [EB/OL]. 2020:

URL    
[2]
中华人民共和国卫生健康委员会. 截至5月25日24时新型冠状病毒肺炎疫情最新情况[EB/OL]. 2020:

URL    
[3]
Rismanbaf A, Zarei S. Liver and kidney injuries in covid-19 and their effects on drug therapy, a letter to editor [J]. Arch Acad Emerg Med, 2020, 8(1): e17.
[4]
Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [J]. N Engl J Med, 2020, 382(13): 1199-1207.
[5]
Sanche S, Lin YT, Xu C, et al. High contagiousness and rapid spread of severe acute respiratory syndrome coronavirus 2 [J]. Emerg Infect Dis, 2020, 26(7): 1470-1477.
[6]
Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China [J]. JAMA, 2020, 323(11): 1061-1069.
[7]
Guan WJ, Ni ZY, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China [J]. N Engl J Med, 2020, 382(18): 1708-1720.
[8]
Cheng Y, Luo R, Wang K, et al. Kidney disease is associated with in-hospital death of patients with COVID-19 [J]. Kidney Int, 2020, 97(5): 829-838.
[9]
Anti-2019-nCoV Volunteers, Li Z, Wu M, et al. Caution on kidney dysfunctions of covid-19 patients [J]. medRxiv, 2020, [https:// doi.org/ 10.1101/ 2020. 02. 08.20021212].
[10]
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study [J]. Lancet Respir Med, 2020, 8 (5): 475-481.
[11]
Hirsch JS, Ng JH, Ross DW, et al. Acute kidney injury in patients hospitalized with COVID-19 [J]. Kidney Int, 2020, 98(1): 209-218.
[12]
Wang L, Li X, Chen H, et al. Coronavirus disease 19 infection does not result in acute kidney injury: an analysis of 116 hospitalized patients from Wuhan, China [J]. Am J Nephrol, 2020, 51(5): 343-348.
[13]
Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [J]. Lancet, 2020, 395(10223): 497-506.
[14]
Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study [J]. Lancet, 2020, 395(10223): 507-513.
[15]
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China [J]. JAMA Intern Med, 2020,[published online ahead of print].
[16]
Xu Z, Shi L, Wang Y, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome [J]. Lancet Respir Med, 2020, 8(4): 420-422.
[17]
姚小红,李廷源,何志承,等.新型冠状病毒肺炎(COVID-19)三例遗体多部位穿刺组织病理学研究 [J]. 中华病理学杂志,2020, 49(05): 411-417.
[18]
Zhou P, Yang XL, Wang XG, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin [J]. Nature, 2020, 579(7798): 270-273.
[19]
Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding [J]. Lancet, 2020, 395(10224): 565-574.
[20]
Hoffmann M, Kleine-Weber H, Krüger N, et al. The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells [J]. bioRxiv, 2020, [https://doi.org/10.1101/2020.01.31.929042].
[21]
Zou X, Chen K, Zou J, et al. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection [J]. Front Med, 2020, 14 (2): 185-192.
[22]
Pan XW, Xu D, Zhang H, et al. Identification of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis [J]. Intensive Care Med, 2020, 46(6): 1114-1116.
[23]
Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies [J]. Nat Rev Nephrol, 2020, 16(6): 308-310.
[24]
Chena G, Zhou YZ, Ma J, et al. Is there a role for blood purification therapies targeting cytokine storm syndrome in critically severe COVID-19 patients? [J]. Ren Fail, 2020, 42(1): 483-488.
[25]
Gao J, Tian Z, Yang X. Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies [J]. Biosci Trends, 2020, 14(1): 72-73.
[26]
Yang Y, Shi J, Ge S, et al. Effect of continuous renal replacement therapy on all-cause mortality in COVID-19 patients undergoing invasive mechanical ventilation: a retrospective cohort study [J]. medRxiv, 2020, [https:// doi.org/ 10.1101/2020.03.16.20036780].
[27]
Liu Y, Sun W, Li J, et al. Clinical features and progression of acute respiratory distress syndrome in coronavirus disease 2019 [J]. medRxiv, 2020, [https://doi.org/10.1101/2020.02.17.20024166].
[28]
Hatem A, Daoud A, Mohamed MM, et al. Survival rate in acute kidney injury superimposed COVID-19 patients: a systematic review and meta-analysis [J]. Ren Fail, 2020, 42(1): 393-397.
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