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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (04) : 181 -185. doi: 10.3877/cma.j.issn.2095-3216.2020.04.007

所属专题: 文献

综述

B淋巴细胞在狼疮性肾炎中的作用研究进展
王尚1, 项丽2, 许国双2,()   
  1. 1. 710038 西安,空军军医大学学员四大队十四队
    2. 710032 西安,空军军医大学第一附属医院肾脏内科
  • 收稿日期:2020-06-18 出版日期:2020-08-28
  • 通信作者: 许国双
  • 基金资助:
    国家自然科学基金(81470993;81272621); 百特公司腹膜透析专项课题(CHN-RENAL-IIS-2012-039); 西京医院新技术新业务(XJGXl5Y45)

Research progress of the role of B lymphocytes in lupus nephritis

Shang Wang1, Li Xiang2, Guoshuang Xu2,()   

  1. 1. The 14th Squadron of the Fourth Team, Air Force Military Medical University, Xi′an 710038
    2. Department of Nephrology, First Affiliated Hospital of Air Force Military Medical University, Xi′an 710032; Shaanxi Province, China
  • Received:2020-06-18 Published:2020-08-28
  • Corresponding author: Guoshuang Xu
  • About author:
    Corresponding author: Xu Guoshuang, Email:
引用本文:

王尚, 项丽, 许国双. B淋巴细胞在狼疮性肾炎中的作用研究进展[J]. 中华肾病研究电子杂志, 2020, 09(04): 181-185.

Shang Wang, Li Xiang, Guoshuang Xu. Research progress of the role of B lymphocytes in lupus nephritis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(04): 181-185.

狼疮性肾炎(LN)是严重威胁我国人民健康的重大疾病。B淋巴细胞既参与系统性损害的病理过程,也参与肾脏疾病的自身免疫发病过程,是导致自身抗体产生和免疫复合物在肾脏沉积、激活补体导致肾脏损害的最大推手。近年来针对B淋巴细胞及其活化途径治疗LN显示出可喜的应用前景。本文就B淋巴细胞在LN中作用研究进展做一简要综述。

Lupus nephritis (LN) is a major disease that seriously threatens the health of Chinese people. B lymphocytes are involved not only in the pathological process of systemic damage, but also in the autoimmune pathogenesis of renal disease, and are the biggest driving force for the production of autoantibodies, the deposition of immune complexes in the kidney, and the activation of complement, which lead to kidney damage. In recent years, the treatment of LN targeting B lymphocytes and their activation pathways has shown promising prospects. This article briefly reviewed the research progress of B lymphocytes roles in LN.

表1 SLE和LN治疗药物及其对B细胞的影响
表2 生物制剂及其对B细胞的影响
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