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中华肾病研究电子杂志 ›› 2020, Vol. 09 ›› Issue (04) : 176 -180. doi: 10.3877/cma.j.issn.2095-3216.2020.04.006

所属专题: 文献

综述

足细胞损伤时细胞周期调控及MDM2-p53通路作用的研究进展
李琦1, 朱晗玉2, 徐莉1, 韩秋霞2, 闫景瑶2, 赵焕焕2, 丁潇楠2, 范秋灵1,()   
  1. 1. 110000 中国医科大学附属第一医院肾内科
    2. 100853 北京,解放军总医院第一医学中心肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心、肾脏疾病研究北京市重点实验室
  • 收稿日期:2019-12-15 出版日期:2020-08-28
  • 通信作者: 范秋灵
  • 基金资助:
    国家自然科学基金(61971441;61671479;81800642)

Research progress on cell cycle regulation and role of MDM2-p53 pathway in podocyte injury

Qi Li1, Hanyu Zhu2, Li Xu1, Qiuxia Han2, Jingyao Yan2, Huanhuan Zhao2, Xiaonan Ding2, Qiuling Fan1,()   

  1. 1. Department of Nephrology, First Affiliated Hospital of China Medical University, Shenyang 110000
    2. Department of Nephrology, First Medical Centre of Chinese PLA General Hospital, Beijing 100853; China
  • Received:2019-12-15 Published:2020-08-28
  • Corresponding author: Qiuling Fan
  • About author:
    Corresponding author: Fan Qiuling, Email:
引用本文:

李琦, 朱晗玉, 徐莉, 韩秋霞, 闫景瑶, 赵焕焕, 丁潇楠, 范秋灵. 足细胞损伤时细胞周期调控及MDM2-p53通路作用的研究进展[J/OL]. 中华肾病研究电子杂志, 2020, 09(04): 176-180.

Qi Li, Hanyu Zhu, Li Xu, Qiuxia Han, Jingyao Yan, Huanhuan Zhao, Xiaonan Ding, Qiuling Fan. Research progress on cell cycle regulation and role of MDM2-p53 pathway in podocyte injury[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2020, 09(04): 176-180.

在肾脏疾病中,足细胞稳态对其功能的维持至关重要。当成熟足细胞受损后,就会因不适当的周期调控而出现有丝分裂灾难。其中MDM2-p53通路参与调节多种细胞周期信号通路,是平衡足细胞周期调控的核心因素,被认为是有前景的治疗靶点之一。本综述就足细胞损伤时的细胞周期信号、MDM2-p53通路作用以及细胞周期调控的相关药物选择进行了综述。

In kidney diseases, podocyte homeostasis is of vital importance to the maintenance of its function. If mature podocytes get injured, mitotic catastrophe may occur due to inappropriate cell cycle regulation. MDM2-p53 pathway is involved in a variety of signal pathways regulating cell cycle, is the core factor to balance podocyte cycle regulation, and is considered one of the promising therapeutic targets. This review summarized the cell cycle signals, role of MDM2-p53 pathway, and the selection of drugs for cell cycle regulation in podocyte injury.

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