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中华肾病研究电子杂志 ›› 2022, Vol. 11 ›› Issue (06) : 347 -352. doi: 10.3877/cma.j.issn.2095-3216.2022.06.009

综述

狼疮性肾炎慢性化中肾脏固有细胞的间充质化研究进展
黄嘉明1, 段红霞2, 赖逾鹏1, 王大吉3, 刘兴娇1, 沈鑫4, 王梅英1,()   
  1. 1. 518035 深圳大学第一附属医院、深圳市第二人民医院风湿免疫科
    2. 100101 北京,中国科学院生物物理研究所、蛋白质与多肽药物重点实验室
    3. 518055 深圳,中国科学院深圳先进技术研究院、深圳合成生物学创新研究院
    4. 518035 深圳大学第一附属医院、深圳市第二人民医院风湿免疫科;515041 汕头大学临床医学院
  • 收稿日期:2022-03-04 出版日期:2022-12-28
  • 通信作者: 王梅英
  • 基金资助:
    深圳市科技创新委员会基金(JCYJ20200109140412476,JCYJ20190809095811254); 院内临床研究项目(20213357002,20213357028)

Progress of research on mesenchymal transformation of renal resident cells in the chronicity of lupus nephritis

Jiaming Huang1, Hongxia Duan2, Yupeng Lai1, Daji Wang3, Xingjiao Liu1, Xin Shen4, Meiying Wang1,()   

  1. 1. Department of Rheumatology and Immunology, Shenzhen Second People′s Hospital, Shenzhen 518035, Guangdong Province
    2. Key Laboratory of Protein and Peptide Drug, Institute of Biophysics of Chinese Academy of Sciences, Beijing 100101
    3. Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology of Chinese Academy of Sciences, Shenzhen 518055, Guangdong Province
    4. Department of Rheumatology and Immunology, Shenzhen Second People′s Hospital, Shenzhen 518035, Guangdong Province; Shantou University Clinical Medical School, Shantou 515041, Guangdong Province; China
  • Received:2022-03-04 Published:2022-12-28
  • Corresponding author: Meiying Wang
引用本文:

黄嘉明, 段红霞, 赖逾鹏, 王大吉, 刘兴娇, 沈鑫, 王梅英. 狼疮性肾炎慢性化中肾脏固有细胞的间充质化研究进展[J]. 中华肾病研究电子杂志, 2022, 11(06): 347-352.

Jiaming Huang, Hongxia Duan, Yupeng Lai, Daji Wang, Xingjiao Liu, Xin Shen, Meiying Wang. Progress of research on mesenchymal transformation of renal resident cells in the chronicity of lupus nephritis[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2022, 11(06): 347-352.

狼疮性肾炎(LN)的肾脏纤维化严重影响系统性红斑狼疮(SLE)患者的预后。肾脏固有细胞间充质化在LN纤维化进展中起关键作用。肾脏固有细胞间充质化早期可促进组织损伤的修复,但也是后期导致病变肾脏进入纤维化的一个关键途径。由于肾脏固有细胞间充质化是一个可逆的过程,所以这为早期抗纤维化治疗提供一个宝贵的时间窗。本文对LN中肾脏固有细胞间充质化的最新研究进展予以综述。

Renal fibrosis in lupus nephritis (LN) seriously affects the prognosis of patients with systemic lupus erythematosus (SLE). Mesenchymal transition of renal intrinsic cells plays a key role in the development of LN fibrosis. Mesenchymal transition of renal intrinsic cells can promote the repair of tissue damage in the early stage, but it is also a key way to lead the diseased kidney into fibrosis in the late stage. As the mesenchymal transition of renal intrinsic cells is a reversible process, it provides a valuable time window for early anti-fibrosis treatment. This article reviewed the latest research on mesenchymal transition of renal intrinsic cells in LN.

图1 肾脏固有细胞间充质化的信号调节通路注:EMT:上皮-间充质转化;Endo-MT:内皮-间充质转化;MET:间充质-上皮转化;BMP:bone morphogenetic protein,骨成形蛋白;HGF:hepatocyte growth factor,肝细胞生长因子;肾脏固有细胞间充质化(EMT/Endo-MT)依赖的信号通路包括TGF-β/Smad、Wnt/β-连环蛋白(β-连环蛋白)、Notch RTK和Hedgehog,TGF-β可以激活上述信号通路,从而诱发肾脏细胞EMT/Endo-MT,促进肾脏纤维化;linaglinpin和metformin、fractalkine、quercetin分别通过抑制上述信号通路,抑制肾脏细胞EMT/Endo-MT,同时诱发肾脏间充质细胞转化为上皮细胞,逆转肾脏纤维化
表1 不同研究阶段的肾纤维化治疗药物总结[46]
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