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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2013, Vol. 02 ›› Issue (03): 134-137. doi: 10.3877/cma.j.issn.2095-3216.2013.03.006

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Biomarkers of acute kidney injury

Rong-shan LI1,()   

  1. 1.Department of Nephrology, Second Hospital of Shanxi Medical University, Shanxi Kidney Disease Institute, Taiyuan 030001, China
  • Online:2013-06-15 Published:2024-12-06
  • Contact: Rong-shan LI

Abstract:

In recent years, the clinical incidence of acute kidney injury (AKI) is increasing, with high mortality and poor prognosis. The key to improve the prognosis of AKI is early diagnosis and early intervention. Traditional markers of AKI, blood urea nitrogen and serum creatinine, cannot early reflect the decrease of glomerular filtration rate (GFR), and can be influenced by a variety of factors not related to GFR changes. In recent years, a number of new biomarkers of AKI have been identified with clinical application prospects, which can reflect the early changes of the renal function, including neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), kidney injury molecule-1 (KIM-1),sodium hydrogen exchanger-3, urinary liver-type fatty acid binding protein (L-FABP), urinary cysteinerich protein 61 (cyr 61), urinary N-acetyl-β-D-glucosaminidase (NAG), and urine fetuin A (fetuin-A). This paper has reviewed the research progress of these biomarkers of AKI.

Key words: Acute kidney injury, Biomarker

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