Research advance in the role of predicting the prognosis of peritoneal dialysis patients by recalculated biomarkers based on clinical laboratory indicators

doi:10.3877/cma.j.issn.2095-3216.2024.04.006

Abstract

Abstract:

Inflammation and impairment of immunity and nutrition are risk factors for poor prognosis in peritoneal dialysis patients. Due to the complex relationship among inflammation, immunity, and nutrition, composite biomarkers may have better clinical prognostic predictive ability than a single biomarker. Current research indicated that some biomarkers recalculated based on clinical laboratory indicators were simple and easy to obtain, which might have a better role in reflecting the status of inflammation, immunity, and nutrition, and in predicting the outcomes of peritoneal dialysis patients. This article reviewed the research progress on the role of biomarkers based on recalculated clinical laboratory indicators in predicting the prognosis of peritoneal dialysis patients, in order to provide new ideas for risk stratification and management of clinical peritoneal dialysis patients.

Key words: New biomarkers, Peritoneal dialysis, Inflammation, Immunity, Nutrition

Xiaoqing Zhang, Wen Tang. Research advance in the role of predicting the prognosis of peritoneal dialysis patients by recalculated biomarkers based on clinical laboratory indicators[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(04): 213-218.

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URL: https://zhsbyjdzzz.cma-cmc.com.cn/EN/10.3877/cma.j.issn.2095-3216.2024.04.006

https://zhsbyjdzzz.cma-cmc.com.cn/EN/Y2024/V13/I04/213

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References 62

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疾病	相关并发症	NLR的意义	文献
心血管方面	心血管死亡率	基线高NLR是PD患者心血管死亡率的危险因素	[9，10]
		基线高NLR是60岁以下PD患者心血管事件及心血管死亡率的危险因素	[11]
	动脉硬化	NLR与PD患者动脉硬化程度呈正相关	[9，13]
	脑卒中	高NLR是PD患者自PD治疗以来首次发生脑卒中的危险因素	[14]
感染方面	腹膜透析相关性腹膜炎	基线高NLR的PD患者无腹膜炎生存率更低	[10]
		基线高NLR值与PD相关性腹膜炎发作时治疗失败的高风险相关	[15]
		PD相关性腹膜炎发病时的腹膜透析液NLR可应用于区分病原体是结核/非结核分枝杆菌感染还是细菌性感染	[16]
	肺炎	高NLR与PD患者自PD治疗以来首次发生肺炎密切相关	[17]
其它	全因死亡率	基线高NLR是PD患者全因死亡率的危险因素	[9，10]
		与基线高NLR值组相比，持续高NLR值组与PD患者全因死亡率的相关性更强	[12]

疾病	相关并发症	NLR的意义	文献
心血管方面	心血管死亡率	基线高NLR是PD患者心血管死亡率的危险因素	[9，10]
		基线高NLR是60岁以下PD患者心血管事件及心血管死亡率的危险因素	[11]
	动脉硬化	NLR与PD患者动脉硬化程度呈正相关	[9，13]
	脑卒中	高NLR是PD患者自PD治疗以来首次发生脑卒中的危险因素	[14]
感染方面	腹膜透析相关性腹膜炎	基线高NLR的PD患者无腹膜炎生存率更低	[10]
		基线高NLR值与PD相关性腹膜炎发作时治疗失败的高风险相关	[15]
		PD相关性腹膜炎发病时的腹膜透析液NLR可应用于区分病原体是结核/非结核分枝杆菌感染还是细菌性感染	[16]
	肺炎	高NLR与PD患者自PD治疗以来首次发生肺炎密切相关	[17]
其它	全因死亡率	基线高NLR是PD患者全因死亡率的危险因素	[9，10]
		与基线高NLR值组相比，持续高NLR值组与PD患者全因死亡率的相关性更强	[12]

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