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Chinese Journal of Kidney Disease Investigation(Electronic Edition) ›› 2025, Vol. 14 ›› Issue (02): 91-96. doi: 10.3877/cma.j.issn.2095-3216.2025.02.005

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Research progress on biomarkers of renal tubulointerstitial fibrosis

Ruimin Zhang1, Zheyi Dong1,(), Qian Wang1, Xiangmei Chen1   

  1. 1. Department of Nephrology, First Medical Center of Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Medical Devices and Integrated Traditional Chinese and Western Drug Development for Severe Kidney Diseases, Beijing Key Laboratory of Digital Intelligent TCM for Prevention and Treatment of Pan-vascular Diseases, Key Disciplines of National Administration of Traditional Chinese Medicine (zyyzdxk-2023310), Beijing 100853, China
  • Received:2024-03-12 Online:2025-04-28 Published:2025-05-12
  • Contact: Zheyi Dong

Abstract:

Renal tubulointerstitial fibrosis represents a universal pathway in the progression of various types of chronic kidney disease to end-stage renal disease, and its severity serves as a critical pathological predictor for renal function and prognosis. With significant progress in the study of the mechanism of occurrence and development of renal tubulointerstitial fibrosis, more and more biomarkers have been discovered and become a new auxiliary tool for judging the degree of renal tubulointerstitial fibrosis,showing early diagnostic advantages. This article aimed to review the blood and urine biomarkers related to renal tubulointerstitial fibrosis from the perspective of renal pathological characteristics and pathophysiological mechanisms combining with animal experiments and clinical research results, in order to provide reference for in-depth research on early and non-invasive diagnosis of renal tubulointerstitial fibrosis and the prognosis of kidney diseases.

Key words: Renal tubulointerstitial fibrosis, Biomarkers

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