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中华肾病研究电子杂志 ›› 2017, Vol. 06 ›› Issue (02) : 54 -57. doi: 10.3877/cma.j.issn.2095-3216.2017.02.002

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蛋白质组学在肾脏疾病研究中的应用
吕杨1, 谢院生1, 陈香美1,()   
  1. 1. 100853 北京,解放军总医院肾脏病科、解放军肾脏病研究所、肾脏疾病国家重点实验室、国家慢性肾病临床医学研究中心
  • 收稿日期:2017-02-13 出版日期:2017-04-28
  • 通信作者: 陈香美

Application of proteomics in kidney disease research

Yang Lv1, Yuansheng Xie1, Xiangmei Chen1,()   

  1. 1. Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing 100853, China
  • Received:2017-02-13 Published:2017-04-28
  • Corresponding author: Xiangmei Chen
  • About author:
    Corresponding author: Chen Xiangmei, Email:
引用本文:

吕杨, 谢院生, 陈香美. 蛋白质组学在肾脏疾病研究中的应用[J]. 中华肾病研究电子杂志, 2017, 06(02): 54-57.

Yang Lv, Yuansheng Xie, Xiangmei Chen. Application of proteomics in kidney disease research[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2017, 06(02): 54-57.

研究肾脏疾病发病机制和生物标志物,有助于临床上提高诊断和治疗水平。蛋白质组学是研究发病机制及生物标志物的重要手段。本文对蛋白质组学的发展历史、主要技术方法以及蛋白质组学在IgA肾病、糖尿病肾病、膜性肾病、急性肾损伤和肾癌研究中的应用做了详尽的阐述,并对日后蛋白质组学在肾脏疾病研究中的应用做了展望。

Study on the pathogenesis and biomarkers of renal diseases can improve the diagnosis and treatment clinically. Proteomics is an important discipline to study the pathogenesis and biomarkers. In this paper, the authors elaborated the context including the development history of proteomics, the main technical methods, and proteomics application in the study of IgA nephropathy, diabetic nephropathy, membranous nephropathy, acute kidney injury, and renal cell carcinoma. A prospect was also made of the application of proteomics in kidney disease research.

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