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中华肾病研究电子杂志 ›› 2014, Vol. 03 ›› Issue (06) : 309 -313. doi: 10.3877/cma.j.issn.2095-3216.2014.06.006

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生物活性多肽与肾脏疾病
张爱华1,(), 吴菲1   
  1. 1.100191 北京大学第三医院肾内科
  • 出版日期:2014-12-15
  • 通信作者: 张爱华
  • 基金资助:
    国家自然科学基金项目(81170706、81341022)

Roles of bioactive polypeptides in kidney diseases

Aihua Zhang1,(), Fei Wu1   

  1. 1.Department of Nephrology,PekingUniversityThirdHospital,Beijing,100191,China
  • Published:2014-12-15
  • Corresponding author: Aihua Zhang
引用本文:

张爱华, 吴菲. 生物活性多肽与肾脏疾病[J/OL]. 中华肾病研究电子杂志, 2014, 03(06): 309-313.

Aihua Zhang, Fei Wu. Roles of bioactive polypeptides in kidney diseases[J/OL]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2014, 03(06): 309-313.

小分子活性物质按照它们内在联系可以归结为生物活性多肽“家系”、单氨酸“家系”、气体信号分子“家系”等多个“家系”。 其中单氨酸家系的代表是同型半胱氨酸;气体信号分子家系的代表是一氧化氮、一氧化碳和硫化氢;而生物活性多肽家系最大,如脑型钠尿肽、 肾上腺髓质素、血管紧张素Ⅱ、 生长素(又称胃饥饿素)、 尾加压素Ⅱ (UⅡ) 以及脂肪细胞因子如脂联素、 瘦素,抵抗素,还有爱帕琳肽以及新近认识的肌肉因子鸢尾素,该家系在肾脏疾病、心血管疾病、糖尿病、肥胖、高血压及动脉粥样硬化中起到重要作用,具有多种生物学效应。 本文主要介绍胃饥饿素、尾加压素Ⅱ、抵抗素、爱帕琳及鸢尾素在肾脏疾病中的作用。

Bioactive small molecules, according to their internal relatio nships, are classified into many families such as active polypeptide family, single amino acid family, and gaseous signal molecules family, etc. Among them, the representative of the single amino acid family is homocysteine; the representatives of the gaseous signal family are nitrogen monoxide, carbon monoxide, and hydrogen sulfide;while the largest families are active polypeptide family and lipid family, including brain natriuretic peptide,adrenomedullin (ADM), angiotensin Ⅱ, auxin (also called ghrelin), urotensin Ⅱ (UⅡ), and adipocytokines such as adiponectin, leptin, resistin, as well as apelin peptide, and the newly-discovered muscle factor irisin which has many biological effects and plays important roles in kidney disease,cardiovascular disease, diabetes, obesity, hypertension, and atherosclerosis. In this paper, we have reviewed the roles of ghrelin, urotensin II, resistin, apelin peptide, and irisin in kidney diseases.

1
蒲丹, 唐朝枢. 关注生物活性小分子物质的研究[J]. 国外医学(生理、病理科学与临床分册), 2004, 24(5): 393-398.
2
何莲, 张爱华. 慢性肾脏疾病与透析患者ghrelin 研究现状[J].中国血液净化, 2005, 4(12): 665-668.
3
Yoshimoto A, Mori K, Sugawara A, et al. Plasma ghrelin and desacyl ghrelin concentrations in renal failure [J]. J Am Soc Nephrol, 2002, 13(11): 2748-2752.
4
Rodriguez Ayala E, Pecoits-Filho R, Heimburger O, et al.Associations between plasma ghrelin levels and body composition in end-stage renal disease: a longitudinal study [J]. Nephrol Dial Transplant, 2004,19(2): 421-426.
5
何莲, 张爱华, 阿拉塔,等. 腹膜透析和血液透析患者血浆Ghrelin 水平的研究[J]. 中国现代医学杂志,2007, 17(10):1153-1156.
6
Yang C, Wang Y, Liu H, et al. Ghrelin protects H9c2 cardiomyocytes from angiotensin Ⅱ-induced apoptosis through the endoplasmic reticulum stress pathway[J]. J Cardiovasc Pharmacol,2012, 59(5):465-471.
7
Ledderose C, Kreth S, Beiras-Fernandez A. Ghrelin, a novel peptide hormone in the regulation of energy balance and cardiovascular function [J]. Recent Pat Endocr Metab Immune Drug Discov, 2011,5(1):1-6.
8
Sun G X, Ding R, Li M, et al. Ghrelin attenuates renal fibrosis and inflammation of obstructive nephropathy[J]. J Urol, 2014, Epub ahead of print.
9
Cheung WW, Mak RH. Ghrelin and its analogues as therapeutic agents for anorexia and cachexia in end-stage renal disease[J].Kidney Int, 2009,76(2): 135-137.
10
Ames RS, Sarau HM, Chambers JK, et al. Human urotensin-Ⅱ is a potent vasoconstrictor and agonist for the orphan receptor GPR14[J]. Nature, 1999,401(6750): 282-286.
11
Douglas SA, Ohlstein EH. Human urotensin-Ⅱ, the most potent mammalian vasoconstrictor identified to date, as a therapeutic target for the management of cardiovascular disease[J]. Trends Cardiovasc Med, 2000, 10(6): 229-237.
12
Bottrill FE, Douglas SA, Hiley CR, et al. Human urotensin-Ⅱ is an endothelium-dependent vasodilator in rat small arteries[J]. Br J Pharmacol,2000,130(8): 1865-1870.
13
Bai Q, Zhang J, Zhang AH, et al. Roles of human urotensin Ⅱ in volume resistance hypertension in peritoneal dialysis patients[J].Ren Fail, 2012,34(6): 713-717.
14
Zoccali C, Mallamaci F, Tripepi G, et al. Urotensin II is an inverse predictor of incident cardiovascular events in end-stage renal disease[J]. Kidney Int,2006,69(7): 1253-1258.
15
Zoccali C, Mallamaci F, Benedetto FA, et al. Urotensin Ⅱ and cardiomyopathy in end-stage renal disease[J]. Hypertension,2008,51(2): 326-333.
16
Langham RG, Kelly DJ, Gow RM, et al. Increased expression of urotensin Ⅱ and urotensin Ⅱ receptor in human diabetic nephropathy[J]. Am J Kidney Dis,2004,44(5): 826-831.
17
白琼,阿拉塔,张爱华,等. 糖尿病患者尾加压素Ⅱ与肾小管损伤标志物的相关性研究. 中华临床医师杂志(电子版), 2013,7(6):2323-2326.
18
Lee DK, Cheng R, Nguyen T, et al. Characterization of apelin, the ligand for the APJ receptor[J]. J Neurochem,2000,74(1): 34-41.
19
Day RT, Cavaglieri RC, Feliers D. Apelin retards the progression of diabetic nephropathy[J]. Am J Physiol Renal Physiol,2013,304(6): F788-F800.
20
Zhang BH, Wang W, Wang H, et al. Promoting effects of the adipokine, apelin, on diabetic nephropathy[J]. PLoS One,2013,8(4): e60457.
21
Wang LY, Diao ZL, Zhang DL, et al. The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis[J]. Amino Acids,2014, 46(12): 2693-2704.
22
Seifirad S, Masoudkabir F. Apelin could reduce risk of contrastinduced nephropathy in patients with congestive heart failure[J].Med Hypotheses, 2013,81(5): 898-900.
23
Malyszko J,Malyszko JS,Pawlak K, et al. Visfatin and apelin, new adipocytokines, and their relation to endothelial function in patients with chronic renal failure [J]. Adv Med Sci, 2008, 53(1): 32-36.
24
Nageav I, Bokarewa M, Tarkowski A, et al. Human resistin is a systemic immune-derived proinflammatory cytokine targeting both leukocytes and adipocytes[J]. PloS One, 2006, 1: e31.
25
Filkova M,Haluzik M,Gay S, et al. The role of resistin as a regulator of inflammation:Implications for various human pathologies[J]. Clin Immunol,2009,133(2): 157-170.
26
Steppan CM, Bailey ST, Bhat S, et al. The hormone resistin links obesity to diabetes[J]. Nature,2001,409(6818): 307-312.
27
Spoto B, Mattace-Raso F, Sijbrands E, et al. Resistin and allcause and cardiovascular mortality: effect modification by adiponectin in end-stage kidney disease patients[J]. Nephrol Dial Transplant,2013,28(Suppl 4): 181-187.
28
Kaynar K, Kural BV, Ulusoy S, et al. Is there any interaction of resistin and adiponectin levels with protein-energy wasting among patients with chronic kidney disease[J]. Hemodial Int,2014,18(1): 153-162.
29
Bostrom P, Wu J, Jedrychowski MP, et al. A PGC1-alphadependent myokine that drives bron-fat-like development of white fat and thermogenesis[J]. Nature,2012,481(7382): 463-468.
30
Ruchala M, Zybek A, Szczepanek-Parulska E. Serum irisin levels and thyroid function-newly discovered association[J]. Peptides,2014,60: 51-55.
31
Wen MS, Wang CY, Lin SL, et al. Decrease in irisin in patients with chronic kidney disease[J]. PLoS One,2013,8(5): e64025.
32
Ebert T, Focke D, Petroff D, et al. Serum levels of the myokine irisin in relation to metabolic and renal function [J]. Eur J Endocrinol, 2014,170(4): 501-506.
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